Man City XI vs RB Leipzig: Confirmed team news, injury latest, predicted lineup for Champions League game
A draw in Germany left the last-16 tie finely poised ahead of the Etihad Stadium meeting.
Pep Guardiola has a fully fit squad available for the second leg after Phil Foden bounced back from a foot injury to start in the win over Crystal Palace on the weekend.
City named De Bruyne and Kyle Walker on the bench at Selhurst Park in what was most likely a rest for the first-choice players.
That saw John Stones return to the starting XI for the first time after over a month out due to a hamstring injury.
The difficult decision for Guardiola is who to drop to bring De Bruyne back into the line-up, with Foden showing the most signs of form in recent weeks and Grealish also impressing.
Bernardo Silva is often one of the first names on the City teamsheet, hence his recent move to an unorthodox left-back role as Ilkay Gundogan and Rodri were kept in the team.
On Monday, De Bruyne appeared alongside Guardiola at the pre-match press conference in a nod towards him starting the game. But the City manager did not go into any detail on his selection against Leipzig.
Predicted Manchester City XI: Ederson; Walker, Akanji, Dias, Ake; De Bruyne, Rodri, Silva; Foden, Haaland, Grealish.