Manchester United XI vs Southampton: Predicted lineup, confirmed team news and injury latest
Mired in a relegation battle, Saints have won two of their last three games in the Premier League including beating Chelsea away from home, making them no pushover for the third-placed Red Devils.
Therefore, Ten Hag is set to pick another strong side on Sunday afternoon – particularly with victory in their Europa League tie against Real Betis all but sealed.
Marcel Sabitzer is a doubt after sitting out the first-leg win over Betis due to an unspecified injury.
Anthony Martial will miss out however with the striker yet to return to full training following a hip issue. Christian Eriksen and Donny van de Beek are also sidelined.
Should Ten Hag want to freshen his line-up up, Aaron Wan-Bissaka replaced Diogo Dalot off the bench on Thursday as their competitive fight for the right-back berth continued.
Jadon Sancho and Facundo Pellistri looked lively off the bench but goals for all four of United’s first-choice attackers should maintain their spots in the line-up, with Marcus Rashford and Luke Shaw taken off early for a rest in a busy run of games.
Predicted Manchester United XI: De Gea; Wan-Bissaka, Varane, Martinez, Shaw; Fred, Casemiro, Fernandes; Antony, Weghorst, Rashford.