The 35-year-old striker sat out the weekend win over Espanyol with an ankle injury in the latest blow of a season littered with fitness worries.
Carlo Ancelotti must decide whether to risk Benzema, who reports suggest could be fit for the Liverpool game, given the Clasico with Barcelona looms large on the horizon.
However, Real will not take the Reds’ visit likely despite a three-goal aggregate lead from the first leg at Anfield.
Antonio Rudiger should return to the line-up after being rested against Espanyol and Nacho Fernandez is most likely to shuffle over to left-back, with David Alaba and Ferland Mendy unavailable.
Eduardo Camavinga, who played on the left last time out, would make way unless Ancelotti opts to rest Toni Kroos or Luka Modric from his midfield.
Rodrygo is set to continue up front if Benzema is absent with Federico Valverde completing the front three opposite Vinicius Jr.
Real will deliver a further team news update when they name their matchday squad to face Liverpool on Tuesday morning.
Predicted Real Madrid XI: Courtois; Carvajal, Militao, Rudiger, Nacho; Modric, Tchouameni, Kroos; Valverde, Rodrygo, Vinicius.